When Amanda’s husband, Chris, interrupted a critical video call, she knew it was time to end things. But things only got worse when he showed up at an official meeting the next day and made a show in front of very important people.
Amanda stared at her laptop screen. She was finishing up with an important meeting with her supervisors at work. Her nerves grated along a knife’s edge, but not because of the video meeting. Her husband, Chris, was approaching the neat and cozy corner she used for working and taking on-camera calls.
“You’re amazing, Amanda,” Mr. Anders said.
For illustration purposes only | Source: YouTube/DramatizeMe
Amanda would’ve hoisted up her biggest and brightest smile, but Chris’s heavy footsteps were closer now; he was almost upon her. She froze. Like a squirrel cornered by a bear, there was nowhere for her to run and no place where she could hide.
Chris slammed his beer down on the writing pad she’d used to take notes, stepping right into her space and her laptop camera’s range. Amanda shrank away from him.
“What are you doing?” Chris asked. “Where’s my food?”
“I’m so sorry,” Amanda said to her supervisors before tilting her head to answer Chris. “I’m just finishing up my meeting, honey.”
She looked on in dismay as her supervisors, Claire and Mr. Anders, looked at each other in confusion. Amanda could still save this. Chris might go away if she could find just the right words or precisely the right way to look at him (once she gathered the courage to look at him at all.) Once he left, she could play the whole thing off as a mistake.
For illustration purposes only | Source: YouTube/DramatizeMe
“Honey, I’m hungry,” Chris said. “You don’t want to upset your hubby, do you?”
His tone of voice was soft, silky, and laden with threats Amanda knew full well he wouldn’t hesitate to follow through on. She looked up at him now—she couldn’t avoid it any longer—and bravely spoke to him as though he were a normal person, not a monster disguised as a human being.
“I just need a few more minutes, honey. Please?” Amanda pleaded. “I’m on a call with my supervisors. We should be finished soon.”
She turned back to face her laptop squarely, but Chris clearly wasn’t done.
“Supervisors?” He chuckled and reached around to grab her chair. “Come on, off you go,” Chris said, giving her chair a little shake. “You know what happens when you work too hard.”
For illustration purposes only | Source: Youtube/DramatizeMe
Indeed, Amanda knew all too well what Chris would do to her for what he perceived as ‘working too hard.’ She smiled at her screen even as her mind filled with howling terror. Some part of herself that felt like it might be vital tore loose inside of her.
Amanda let Chris shoo her away from what might be the most vital meeting of her career because she ultimately had no choice. She never had a choice. A familiar darkness closed in around her as she walked to the kitchen.
“And get everything on the table in fifteen minutes,” Chris called after her.
“Of course, honey,” Amanda chirped as her auto-pilot persona took over.
“I will talk to your supervisors myself,” Chris said.
Mr. Anders, one of Amanda’s supervisors, spoke to him. “Chris, Amanda is indispensable for the meeting tomorrow. Her presence is crucial for our success, do you understand?” he stated firmly.
For illustration purposes only | Source: YouTube/DramatizeMe
Chris’s demeanor faltered slightly. “Oh, yeah, yeah, sure thing,” he dismissed.
As Amanda left to attend to Chris’s demands for food, Chris remained on the call, his disruptive behavior leaving an indelible mark of chaos that tainted the professionalism of the meeting.
***
Amanda found herself in the sanctuary of her kitchen a few hours later, the remnants of dinner scattered across the countertops. The clinking of dishes filled the air as she diligently washed and dried them, methodically moving through the routine chores.
How did it come to this? Amanda’s mind raced as she scrubbed a stubborn stain off a plate. My career hanging by a thread because of my husband.
For illustration purposes only | Source: Youtube/DramatizeMe
The clatter of plates faded into the background as Amanda’s thoughts tugged at her. I’ve worked so hard for this and sacrificed so much…
She dried a glass, the transparency reflecting the chaos she couldn’t quite see through. Where do I draw the line? Why am I still with him?
The dishes gleamed at last. Yet, Amanda’s inner conflict lingered, simmering beneath the surface, unresolved and weighing heavily on her conscience.
***
The following day, Mr. Anders attempted to maintain decorum, apologizing to the investors immediately. “Apologies for the delay. Amanda will be here shortly. Thank you for being so patient.”
For illustration purposes only | Source: Youtube/DramatizeMe
Mr. Whitney, a composed figure among the investors, nodded understandingly. “We’ll wait. We’re eager to hear from Amanda,” he reassured, his gaze flickering toward the entrance.
Finally, Amanda rushed in, her chest moving rapidly. Determination glinted in her eyes, though the darkness below her eyes showed her fatigue. “Thank you for waiting. I’m so sorry,” she managed, still breathless.
Chris barged into the room before she could collect her thoughts.”What’s the fuss about? Mind if I join?” he interjected, a smirk playing on his lips as he glanced around.
He strolled over to Mr. Whitney, fixating on the watch adorning his wrist. “Fancy watch. How much did you spend on that?” Chris prodded, ignoring or unaware of the shocked and confused faces around him.
For illustration purposes only | Source: YouTube/DramatizeMe
The investors exchanged bemused glances as Chris continued, his demeanor unapologetic. “Money talks, right? Let’s get to it,” he declared.
Amanda tried to rein him in. “Chris, not now, please,” she implored, sweat beading on her forehead.
Mr. Anders beckoned Claire urgently, guiding her to the corridor outside the meeting room where Chris lingered, an unsettling air of disruption trailing him. “We need to contain this,” he whispered urgently before calling out Amanda’s husband. “Chris, how about a tour of our facilities? We’ll show you around while Amanda continues the meeting.”
Chris’s expression shifted, a smug grin playing on his lips. “Sure thing, boss. Lead the way!” he mocked, his eyes darting mischievously.
Mr. Anders led Chris along the corridor. “Claire here will assist you,” he explained, turning to Claire with a forced smile.
For illustration purposes only | Source: YouTube/DramatizeMe
Claire nodded, albeit reluctantly. “Of course, Chris. Let’s start with the main office area,” she suggested, pretending this was perfectly normal. Mr. Anders returned to the meeting, and Chris’s expression shifted from sarcastic and smiley to something else.
Claire noticed the change quickly but had to pretend. The investor meeting was crucial. “Show me around, girl,” Chris demanded, his voice like a sharp knife. “Huh-huh, do what your boss said. You know what to do if you want things to run smoothly, sweetheart.”
***
Amanda battled to maintain her professional facade despite the sweat beading her entire body and the heavy weight of her eyes. She glanced at the investors, trying to forge ahead with the presentation. “Apologies for the interruption,” she began and tried to direct everyone’s attention to the projection on the wall.
But as Amanda lifted her hand to point at something, her body gave up. She staggered slightly, her vision blurring. The room spun around her, a nauseating dizziness enveloping her senses as she finally fell onto the meeting room carpet.
For illustration purposes only | Source: YouTube/DramatizeMe
“Give her some water,” Mr. Whitney commanded, concerned. The investors exchanged concerned glances, their murmurs of worry filling the air.
Mr. Anders’s composure snapped. “This is unacceptable!” he barked, his frustration palpable as he blamed Amanda, his voice resonating with visible anger. “Get up, Amanda! We need to proceed!”
“She needs help,” Mr. Whitney insisted, frowning at Mr. Anders. Mr. Morgan helped Amanda get up and seated on the table, but before they could move on, the familiar dial tone of a video call interrupted everyone.
It came from Mr. Anders’s private office computer. He hesitated but answered the call. “What’s happening there?” he asked, his anger momentarily diverted, replaced by shock.
The screen flickered to life, revealing Chris’s overbearing presence in Mr. Anders’ office, standing imposingly close to Claire, who was cowering on a couch, trying to dislodge the heavy man’s hands from her face.
For illustration purposes only | Source: YouTube/DramatizeMe
The investors’ faces twisted in outrage, and all stood, calling for security and Mr. Anders to do something. But it was Amanda who acted first despite her earlier collapse. “I need to stop this,” she declared, raising her chin.
This has gone too far, Amanda thought, her heart racing with concern for Claire’s safety. The investors followed behind her.
“Wait, what’s going on?” Mr. Anders asked, his voice far behind everyone else. “We need to get back to the meeting!”
“Chris, leave her alone!” Amanda’s sharp command cut through the tension as she entered Mr. Anders’s office. Mr. Whitney and Mr. Morgan hurried after her.
Chris stood there, hands at his side, now subdued in the face of his audience. “I didn’t do anything!”
“You’ve gone too far this time!” Amanda’s voice echoed through the office, her eyes blazed daggers at her husband.
Mr. Whitney and Mr. Morgan swiftly intervened, taking control of the situation, their focus restraining Chris until security arrived. Chris was escorted out, but his voice boomed through the corridor. “I didn’t do anything wrong! You all know they want me! Especially her!” He pointed a shaky finger at Amanda, a manic smirk contorting his features.
For illustration purposes only | Source: YouTube/DramatizeMe
“Enough, Chris!” Amanda’s voice cut through the air, firm and unwavering. “You’ve done enough. It’s over.”
Once her husband was finally out of earshot, Amanda noticed Mr. Anders’ angry face. Smoke was almost coming out of his ears. “This is an outrage! You two have ruined everything! You—” His tirade was abruptly interrupted as Mr. Whitney and Mr. Morgan intervened.
“Mr. Anders, enough!” Mr. Whitney’s barked, one hand raised to stop him. “Your lack of leadership exacerbated this situation.”
“Exactly,” Mr. Morgan chimed in, his eyes unwavering. “Amanda and Claire did everything to salvage the meeting despite the chaos caused by your neglect. This is on you, not them.”
For illustration purposes only | Source: YouTube/DramatizeMe
Mr. Anders, seething with indignation, glared at the investors. “How dare you interfere in my business!”
Mr. Whitney shook his head, unfazed. “This isn’t how you treat your employees. We value their dedication and professionalism, something you’ve failed to recognize.”
“Furthermore,” Mr. Morgan added sternly, “they’re too good to work for you. We’re offering Amanda and Claire positions at our investment fund. They deserve better.”
Mr. Anders, his face flushed with anger, stormed out of the office. In the wake of his departure, the investors turned their attention to Amanda and Claire, commending them for their resilience and offering them opportunities in a more supportive and appreciative work environment.
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We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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