The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Kathy Bates Reveals the Shocking Struggles She Had to Conquer to Achieve Success
Actress Kathy Bates, famous for her strong performances, has recently shared that she is dealing with a serious long-term health condition. Even with this challenge, she continues to motivate us with her determination and love for acting.
Bates started her acting career in New York in 1970. Even though she didn’t fit the typical image of a leading lady, she kept going and found success as a character actor.
Looking back on those early years, Bates said, “I was never the young, pretty lead. I’ve always been more of a character actor. When I was younger, it was tough because I didn’t look like the typical star. It wasn’t just about getting work; it was also about dealing with how people saw me.”
Kathy Bates had a major career breakthrough at 42 when she played a crazy fan in the film “Misery,” which won her an Academy Award for Best Actress. Even though she often had few role options, Bates found strength and success in the characters she played.
Besides her acting, Bates has also directed episodes for well-known TV shows like “Homicide: Life on the Street,” “NYPD Blue,” “Oz,” and “Six Feet Under.” She has definitely made a strong impact in the entertainment world.
But Kathy Bates has also had health challenges in her personal life. She fought cancer twice: first with ovarian cancer in 2003, and then with breast cancer in 2012. After her breast cancer surgery, she was diagnosed with lymphedema and became a spokesperson for the Lymphatic Education & Research Network.
Lymphedema is a condition that causes swelling in the arms or legs. Despite dealing with this challenge, Kathy Bates has shown amazing strength by managing her symptoms through weight loss and wearing compression sleeves. She emphasizes the importance of taking things slow and focusing on each task, refusing to let the condition control her life. Bates uses her own experiences to inspire others with lymphedema to live fully.
In addition to raising awareness for lymphedema, Bates is committed to funding research for the condition. Even with her diagnosis, she continues to take on roles she loves and advocate for the cause. She demonstrates that it’s possible not just to cope with a chronic health condition, but to truly thrive.
Let Kathy Bates’ inspiring story remind you to tackle your own challenges head-on. Share this article to raise awareness and encourage others in their battle with lymphedema.
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