The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Woman Uses Face Cream Mom-in-Law Gave Her, Faints after Looking in Mirror the Next Morning – Story of the Day
Pauline’s birthday took an unexpected turn when she applied a new cream gifted by her estranged mother-in-law, Annalise. But she never imagined that she would be staring at the mirror in horror the next morning. What had Annalise done?
The aroma of freshly baked cake wafted through Pauline’s modestly decorated living room.
Streamers hung from the ceiling, and a small pile of gifts adorned the coffee table.
Pauline, a woman in her early thirties, with warm brown eyes and a hesitant smile, sat on the couch, surrounded by her immediate family.
For illustration purposes only | Source: Midjourney
Her husband, Carl, a tall man with kind features, handed her a gift. “This one’s from Mom,” he said, his voice tinged with surprise.
Pauline’s eyes widened as she accepted the package. She glanced at Annalise, her mother-in-law, who sat stiffly in an armchair across the room.
The older woman’s face was neutral, but her eyes betrayed a hint of nervousness.
“Thank you,” Pauline said softly, carefully unwrapping the gift.
For illustration purposes only | Source: Pexels
Inside was an expensive skincare set from a well-known brand.
Pauline’s surprise was evident as she examined the products. “Oh, wow. I love this brand,” she exclaimed, looking up at her mother-in-law. “Thank you, Annalise. This is very thoughtful.”
Annalise nodded curtly. “I read that women like these things nowadays. I ordered it online.”
Despite the kind and seemingly normal exchange, everyone in the room could sense the tension.
For illustration purposes only | Source: Pexels
For years, Pauline and Annalise had been at odds, to put it nicely. They had vastly different personalities, and the older woman wasn’t keen on boundaries.
It wasn’t until Carl threatened to cut contact that Annalise became more reserved and did not cause so many conflicts with Pauline.
Therefore, this gesture, however small, felt like a tentative step towards reconciliation.
As the party wound down and guests left, Pauline found herself in the bathroom, examining the skincare products.
For illustration purposes only | Source: Pexels
Carl joined her, wrapping an arm around her waist.
“I’m shocked that your mother bought me something,” Pauline said, unscrewing the lid of one of the creams.
Carl nodded with a hopeful smile on his face. “I’m just as surprised. But this could be good for all of us, right?”
Pauline agreed, applying the cream to her face. “These things are expensive. I can’t wait to see how my skin looks in the morning.”
But as they settled into bed that night, neither could have expected what happened the following morning.
For illustration purposes only | Source: Pexels
***
Pauline stirred awake and felt the soft morning light filtering through the curtains. However, it wasn’t pleasant as always. Something felt off.
Her face burned, and her eyelids felt heavy and crusty. Blinking slowly, she tried to focus on her surroundings.
“Ouch,” she mumbled, reaching for her face. The moment her fingers touched her skin, a searing pain shot through her. “Oh God!”
For illustration purposes only | Source: Midjourney
She bolted upright, ignoring the way her skin seemed to pull and crack with every movement. Stumbling to the bathroom mirror, Pauline let out a strangled gasp at her reflection.
Her face was a mess of angry red patches and peeling skin. Some areas looked raw as if the top layer had been completely stripped away.
“Carl!” she cried out, her voice trembling with fear and pain.
Her husband rushed to her side, his face paling at the sight. “Jesus, Pauline! What happened?”
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Before she could respond, Pauline’s vision blurred, and she felt herself falling. The last thing she heard was Carl’s panicked shout as darkness enveloped her.
When Pauline regained consciousness, she found herself in a white, sterile hospital room. The steady beep of monitors filled the air, and the smell of antiseptic stung her nostrils.
Carl sat beside her, his face etched with worry. “Pauline, baby. How are you feeling?” he asked, squeezing her hand gently.
For illustration purposes only | Source: Unsplash
Before she could respond, a doctor entered the room. “Mrs. Patterson, I’m Dr. Rawlings,” she introduced herself with a professional but kind tone. “Can you tell me what happened?”
Pauline recounted using the skincare products she had received as a gift. As she spoke, realization dawned on her face. “The cream… it must have been the cream,” she whispered, gaping at her husband.
Dr. Rawlings nodded gravely. “The cream you used was a professional-grade chemical peel, not meant for home use. It’s typically only used in medical spas under strict supervision.”
For illustration purposes only | Source: Unsplash
Pauline’s mind raced as she considered what the doctor said. After a few seconds, she connected the dots.
“Annalise,” she breathed, turning again to Carl with wide, horrified eyes. “Your mother did this on purpose!”
Carl’s face hardened as he started shaking his head. “I can’t believe she would go this far,” he muttered, frowning.
As if summoned by their words, Annalise burst into the room, and her face was full of concern. “Carl! Your sister called me with the news. Pauline, what happened?“
For illustration purposes only | Source: Pexels
Pauline’s reaction was immediate and visceral. “You did this!” she screamed as tears streamed down her damaged face. “YOU HORRIBLE WOMAN! YOU RUINED MY FACE ON PURPOSE!”
Annalise recoiled. “What? No! I didn’t! I swear!” she said, hurt, and placed a hand on her chest. “I… I saw the products online, and they had good reviews… I didn’t know they were so strong…”
Carl stood up, and anyone could see the rigidness of his body. He was trying to hold back his anger. “Mom, you need to leave. Now. We don’t want anything to do with you anymore.”
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Annalise tried to protest, but several nurses came in to usher her out of the room. When she was gone, Pauline collapsed into sobs, overwhelmed by the idea that her mother-in-law could cause her such harm.
***
Hours passed in a blur of doctors, nurses, and worried family members.
Pauline drifted in and out of sleep thanks to the pain medication which had dulled her senses. When she awoke again, she found Carl speaking quietly with Dr. Rawlings near the door.
For illustration purposes only | Source: Midjourney
“Carl?” she called out weakly.
He was by her side in an instant, relieved. “Hey, how are you feeling?”
“Like my face is on fire,” Pauline replied, attempting a smile. “What’s going on?”
Carl took a deep breath, seeming to brace himself. “Mom… she’s been trying to explain something.”
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Pauline felt her heart rate increase, and the monitor beside her began to beat faster. “What could she possibly have to say?”
“She said she didn’t do this on purpose,” Carl began cautiously. “She says she’s been seeing a therapist, trying to work on herself and our family relationship.”
Pauline’s brow furrowed, wincing at the pull of her damaged skin. “A therapist? Your mother?“
For illustration purposes only | Source: Midjourney
Carl nodded, looking as surprised as Pauline felt. “I know, it’s hard to believe. But she showed me some receipts, and her therapist even called to confirm.”
As Carl explained further, Pauline’s anger began to give way to confusion and a glimmer of something else… hope?
“She told me that she saw the products online, recommended by some influencer,” Carl continued, rolling his eyes at the idea. “She didn’t know it was professional-grade. She was just trying to get you something nice.”
For illustration purposes only | Source: Pexels
Pauline closed her eyes, processing this information. Could it be true? After years of hostility, could Annalise truly be trying to make amends?
“I think… I think I’d like to talk to her,” Pauline said finally, although she was still in disbelief.
When Annalise entered the room, her usual composed demeanor was nowhere to be seen. Her eyes were red-rimmed, and her hands twisted nervously in front of her.
For illustration purposes only | Source: Pexels
“Pauline, I… I’m so sorry,” Annalise began, her voice almost breaking. “I never meant for this to happen. I’ve been trying so hard to be better, to fix things between us. I know I haven’t been the best or easiest mom-in-law…”
As Annalise spoke, pouring out her heart about her therapy sessions and her genuine desire to be a part of their family without their previous animosity, Pauline felt something shift within her.
The anger and resentment that had built up over the years began to disappear. She always felt inclined to believe people who truly wanted to change.
For illustration purposes only | Source: Midjourney
Pauline was big on second chances, but it was still difficult.
“I want to believe you,” she said softly. “I want us to move past this. For Carl, for the kids… for all of us.”
Annalise’s eyes filled with tears. “You have no idea how much that means to me. I promise I’ll do whatever it takes to make this right.”
While they talked, Carl brought in the skincare products for the doctors to examine.
For illustration purposes only | Source: Pexels
It was confirmed that while the products were indeed professional-grade, they were readily available online without proper warnings.
“I’m afraid, Mrs. Patterson, that you should’ve been more careful with the instructions here,” Dr. Rawlings said carefully. “This chemical peel says it’s strong and can’t be used for over five minutes.”
“So, it’s my fault?” Pauline asked, shocked. Carl held her hand in comfort, and Annalise shook her head.
“No, it’s an easy mistake, unfortunately,” the doctor continued. “But it was dangerous.”
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After the doctor left, Pauline laughed awkwardly, and the sound broke the tension. She and Carl apologized to Annalise for immediately jumping to conclusions, but the older woman understood why.
“After how I behaved before, I understand,” Annalise said and smiled at Pauline through teary eyes. It was a genuine grin that only proved how sincere she was.
So, in that hospital room, a new chapter began for their family.
For illustration purposes only | Source: Midjourney
Pauline reached out, taking Annalise’s hand in hers. “Let’s start over,” she said, smiling back. “Clean slate. Just… maybe hold off on any more gifts for a while, okay?”
Annalise let out a tearful laugh, nodding vigorously. “Deal.”
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