The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
My Stepmom Covertly Called Off My Prom Hair Appointment to Spoil My Evening – Yet She Was Stunned When a Limousine Arrived for Me
Yeah, that woman cannot stand me.
It all started 7 years ago, after my mom passed away from a cold that just wouldn’t go away. Before I knew it, my dad was seeing Carla, and a year later, he married her.
“Your father doesn’t waste any time, does he?” my aunt sniffed on the day of the wedding. “And who is Carla anyway? She’s nothing compared to your mom!”
Carla was fine at first. I mean, she tried hard to get me on her side. But slowly, the passive-aggressive jabs started piling up. I remember once, I caught her staring at me.
“You look too much like your mother, Emily,” she said. “It actually pains me to look at you. No wonder your father gives Mason more attention. He’s closer to Mason right now, isn’t he?”
I sighed and ignored her, trying not to let her words get to me.
My dad, of course, didn’t notice a thing. It was like he couldn’t—or just wouldn’t—see how Carla treated me. And she loved that. She loved being the only one ready to taunt me.
Anyway, fast forward to prom season. Like every other girl in my class, I was dreaming of the perfect night. I saved up enough babysitting money for months to buy a gorgeous violet dress.
I couldn’t help but wish that my mother was around to spend these moments with me.
But that’s why I chose the violet dress. It was her favorite color.
Prom was going to be my night. I just knew it.
Whenever I thought about it, I just felt like something magical was going to happen at prom. To make myself feel even better, I booked a hair appointment at a fancy salon. All my friends were going there too.
Everything was set.
But then the big day came, and Carla made sure to ruin it.
I went to the salon, all excited, but when I got there, the receptionist looked at me, confused.
“Emily? Are you sure?” she asked, looking at her computer screen. “Zelda told me that you canceled?”
“I didn’t!” I exclaimed. “Why would I? Prom is this evening!”
“Calm down, honey,” the receptionist said. “I’ll get Zelda.”
I waited impatiently while she went to get the hairdresser. Finally, they returned.
The hairdresser looked uncomfortable.
“I got a call earlier today saying that you wanted to cancel your appointment, Emily. I assumed that it was your Mom?”
My heart dropped. Canceled? How? I didn’t cancel it! What mom?
I was still processing everything when I looked over and saw her.
Carla.
Sitting there, getting her hair done. Of course.
She saw me and just smirked, her eyes cold as steel. Carla had canceled my appointment.
“Is there any way that you could still schedule me in?” I asked Zelda.
She shook her head sadly.
“I’m sorry,” she said. “When your appointment was canceled, a woman called in and booked her own. All of our slots are taken. I’m sorry, honey.”
I stood there in shock. So, Carla had called pretending to be me? Pretending to be my mom? And then she took my appointment so that she could watch me be disappointed?
Sick.
I barely managed to keep it together as I ran out of the salon, my head spinning. I felt nauseous.
My perfect prom? It was just falling apart around me. By the time I got home, I locked myself in my room, tears pouring down my face.
I sat at my dressing table trying to fix my hair on my own, but nothing looked good. I felt stupid for telling Carla my plans in passing.
See what had happened?
I looked at my dress, hanging off a hanger.
I wasn’t even sure that I wanted to go to prom anymore.
I sat there, looking at my makeup sitting on my dressing table and wondered if it was even worth it. I mean, what was the point? I was already upset and didn’t feel like anything good was going to come from this.
Suddenly, I heard this loud honking outside. I ignored it at first, thinking it was just a random car.
A teenage girl’s dressing table | Source: Midjourney
A teenage girl’s dressing table | Source: Midjourney
But it didn’t stop.
I wiped my eyes with the back of my hand and dragged myself to the window, fully expecting to see commotion on the road. But when I looked out, my jaw dropped.
A glossy black limousine was parked in front of our house.
I thought it was some sort of mistake. There was no way that the car was for me. My friends’ parents had said no when we first talked about it months ago. But still, I ran downstairs.
I stood at the doorway, waiting for something to happen. The driver stepped out and walked up to our front door. My dad, who had been as clueless as ever during all of this, stood on our porch, looking as confused as I felt.
“I’m here for Miss Emily, sir,” the driver said, holding out a small card.
Miss Emily? Me?
“She’s right here,” my dad said, nodding to me.
I hesitantly took the card from my dad’s hand and opened it. Inside, written in neat handwriting, were the words:
To my beautiful sister, Emily. I know you’ve had a rough time lately, but you deserve the best night ever! Enjoy the limo, and don’t worry about a thing. I’ve been saving all my birthday and Christmas money.
Have a magical night, sis.
Love, Mason.
Mason? My 11-year-old brother did this?
I burst into tears all over again, but this time from pure shock and gratitude. I ran upstairs to find Mason in his room, grinning like he’d just pulled off the ultimate prank.
“I heard Mom on the phone this morning,” he said, shrugging like this wasn’t a big deal. “I knew that it wasn’t fair at all.”
Turns out that he had overheard Carla canceling my hair appointment, and in true little brother fashion, took matters into his own hands.
“But did you really use your money?” I asked him, feeling horrible.
“Not really,” he grinned. “See, Mom has been saving up money to buy some fancy diamond necklace. She’s been showing Dad the necklace, hoping that he would get it for her. But he said no.”
Good for you, Dad, I thought.
“Anyway, after I heard her phone call, she left home. So, I took some of the money from her stash, and went to Mr. Johnson next door. He owns the limo company, remember?”
But Mason didn’t stop there.
“There’s more, Em,” he said. “Mrs. Evans, from across the road? Her daughter is a stylist at the mall. She’s coming here to do your hair and makeup soon.”
Just as the words left his mouth, the doorbell rang.
“That should be her!” Mason said. “Go wash your face, I’ll send her up.”
When did Mason grow up? I wondered as I did what he said.
Twenty minutes later, I went from crying in my bedroom to looking like a princess. I just wished my mom was around to fuss over me. To take endless photos and tell me how proud she was of me. I wanted a hug from her more than anything.
But still, Mason had saved prom!
When Carla drove into our driveway, I was already outside, stepping into the limo like a movie star. Her jaw dropped. And she got out of the car and just stood there, stunned.
Her face? Oh my God. I wish I had a picture of her expression. I would have stuck it on my mirror!
“Richard? Did you do this?” I heard her shriek to my father before the driver closed the door.
Moments later, the driver whisked me away.
Prom was everything I had hoped for. When I arrived at the hall in the limo, heads turned. I was glowing, and I knew it. For the first time in a long time, I felt like my mom was right there with me.
The whole night was pure magic. Dancing, laughing with my friends, and just forgetting all the drama at home.
As for Carla, I hope she learned a lesson. You can’t mess with someone’s joy and get away with it… especially if your son is going to come in and save the day!
What would you have done?
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