Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
✔ High fever
✔ Excessive night sweats
✔ Extreme fatigue
✔ Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
✔ Severe swelling in lymph nodes (especially in the neck)
✔ CT scan abnormalities indicating TB inflammation
✔ Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
🔴 Severe chills and fever
🔴 Uncontrollable night sweats
🔴 Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
✔ High-dose intravenous (IV) steroids for five days to calm the immune system
✔ A slow transition to oral steroids for three months
✔ Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
🔹 Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot.
🔹 Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications.
🔹 Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
⚠️ Myocarditis (heart muscle inflammation)
⚠️ Pericarditis (inflammation around the heart lining)
⚠️ Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
Dan Haggerty, Who Played Grizzly Adams
In the 1974 film “The Life and Times of Grizzly Adams” and the NBC television series of the same name, Dan Haggerty portrayed a kind mountain man with a lush beard and a bear named Ben. Haggerty passed away on Friday in Burbank, California.
He was seventy-three.
According to his buddy and manager Terry Bomar, the cause was spine cancer.
Mr. Haggerty was employed in Hollywood as an animal trainer and stuntman when a producer asked him to reprise portions of the film’s opening sequences, which were about a woodsman and his bear.
Based on Charles Sellier Jr.’s novel “The Life and Times of Grizzly Adams,” it narrated the tale of a man from California who runs away from the woods after being wrongfully convicted of murder. There, he befriends the local wildlife and tames an abandoned bear.
Mr. Haggerty consented, provided that he may do the full film. After being remade for $165,000, the movie finally brought in close to $30 million from ticket sales. After that, it was made into a television series, and in February 1977, Mr. Haggerty returned to his environmentally conscious duty as the forest’s defender and animal buddy.
John Leonard described the first episode in The New York Times as “lukewarm to the heart.” Mad Jack (Denver Pyle) and the honorable red man Makuma (Don Shanks) bring bread and advise to the man and bear who have taken up residence in a log cabin. Bear washes his fur while the man traps his as they depart the cabin. There’s also a lot of connecting with nature, raccoons, owls, deer, bunnies, hawks, badgers, cougars, and a lump in the throat.
Warm and nostalgic, the show won over fans to Mr. Haggerty, who went on to win the 1978 People’s Choice Award for best new series actor. “Grizzly Adams” gave rise to two sequels: “Legend of the Wild,” which aired in 1978 and was eventually released in theaters in 1981; and “The Capture of Grizzly Adams,” which aired as a TV movie in 1982 and saw Adams being brought back to his hometown by bounty hunters in order to clear his record.
On November 19, 1942, Daniel Francis Haggerty was born in Los Angeles. After his parents divorced when he was three years old, he had a difficult upbringing and repeatedly escaped from military school. Eventually, he moved in with his actor father in Burbank, California.
He wed Diane Rooker at the age of 17. The union broke down in divorce. In 2008, he lost his second wife, Samantha Hilton, in a motorbike accident. His children, Don, Megan, Tracy, Dylan, and Cody, survive him.
In his debut movie, “Muscle Beach Party” (1964), he starred with Frankie Avalon and Annette Funicello as physique builder Biff. Then came came cameos in nature and motorcycle movies, such as “Biker With Bandana” and “Bearded Biker.” In “Easy Rider,” he made a fleeting appearance as a visitor to the hippie commune visited by Dennis Hopper and Peter Fonda.
In reality, Mr. Haggerty kept a variety of wild animals that he had either tamed from birth or rescued from harm on his tiny ranch in Malibu Canyon. His abilities brought him work as a stuntman and animal trainer on the television shows “Daktari” and “Tarzan,” in addition to sporadic roles in movies. “People magazine didn’t like actors jumping on them,” he said in 1978.
He acted as a Siberian tiger trapper in “Where the North Wind Blows” (1974), one of his outdoor-themed flicks, and in “The Adventures of Frontier Fremont” (1976). In the David Carradine movie “Americana,” he had an appearance as a dog trainer (1983). He portrayed a figure who was strikingly similar to Grizzly Adams in the movies “Grizzly Mountain” (1997) and “Escape to Grizzly Mountain” (2000).
As his career faded, Mr. Haggerty starred in horror movies such as “Axe Giant: The Wrath of Paul Bunyan” (2013), “Terror Night” (1987), and “Elves” (1989), in which he played an inebriated mall Santa. He was given a 90-day jail sentence in 1985 for supplying cocaine to two police agents who were undercover.
A negligent diner carrying a flaming cocktail ignited Mr. Haggerty’s well-known beard in 1977. He attempted to put out the fire, but instead burned his arms in the third degree. He was sent to a hospital where he would have therapy that would likely take a month.
“For the first few days, I was like a wounded wolf trying to heal myself—I just laid in the dark room drinking water,” he said to People. “Nurses urged me to open the curtains and attempted to give me morphine.” But occasionally, animals have better medical knowledge than humans. After ten days, he left the hospital on foot.
Leave a Reply