Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
✔ High fever
✔ Excessive night sweats
✔ Extreme fatigue
✔ Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
✔ Severe swelling in lymph nodes (especially in the neck)
✔ CT scan abnormalities indicating TB inflammation
✔ Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
🔴 Severe chills and fever
🔴 Uncontrollable night sweats
🔴 Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
✔ High-dose intravenous (IV) steroids for five days to calm the immune system
✔ A slow transition to oral steroids for three months
✔ Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
🔹 Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot.
🔹 Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications.
🔹 Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
⚠️ Myocarditis (heart muscle inflammation)
⚠️ Pericarditis (inflammation around the heart lining)
⚠️ Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
My Ex’s Mom Invited Me to Her Wedding but When I Arrived, I Realized It Was All a Set-up
When Hayley’s ex’s mom invites her to design a wedding dress for her big day, it seems strange, but nothing prepares Hayley for the truth. What follows is a confession, a second chance at love, and a surprise she never saw coming. Sometimes, life gives you the most unexpected twists…
It had been three years since Adam and I broke up, but I still couldn’t shake him. Five years of love doesn’t just disappear overnight. His sudden breakup was like a sucker punch with no explanation, no closure, just silence.
It was just done.
An upset woman | Source: Midjourney
Then, about a year ago, he started dating her. My former friend, Miranda. If betrayal had a face, it was hers, plastered all over social media with captions of the two of them:
When you know, you know, and The best thing that ever happened to me!
I told myself to block her, to stop looking, but I didn’t. Every photo, every grin, every comment about her “forever love” felt like salt in an open wound.
A laptop opened to social media | Source: Midjourney
I never stopped loving him. That’s the sad, honest truth. Pathetic, I know. I wasn’t able to date anyone seriously since him.
So when Adam’s mom, Lena, called me out of the blue last month, I thought I was hallucinating.
We never exactly got along. She had always been polite but distant, like she was sizing me up and always finding me lacking something or the other.
A smiling older woman | Source: Midjourney
After the breakup, I assumed I’d never hear from her again. But there she was, on the other end of my phone, her voice strangely warm.
“Hello, sweetheart,” she said. “I know this might be unexpected, but I have a favor to ask, Hayley.”
Lena told me that she was getting married. Married! And she wanted me to design her wedding dress. She gushed about how I’d become one of the most sought-after seamstresses in the city.
A woman talking on the phone | Source: Midjourney
“I’ve always admired your work, Hayley,” she said softly. “And I trust you. I know you’d create something perfect just for me.”
Trust? Admiration?
From Lena?
I nearly dropped the phone. I couldn’t figure out what game she was playing. My instincts screamed at me to say no, to hang up and block her number. And truly be done with that entire family.
A smiling older woman | Source: Midjourney
But she begged. And how could I say no? She said that no one else could do it justice and that she’d forever be grateful.
“Nobody else will do things that will suit my age and my figure! And make me something dream-worthy, Hayley. Please?”
I don’t know why I said yes. Maybe there was a part of me that wanted to feel close to Adam again. Or maybe I just couldn’t resist the curiosity clawing at me.
Either way, I agreed.
A sketch of a wedding dress | Source: Midjourney
Over the next few weeks, I poured myself into the dress. The fabric was like spun clouds, soft and ethereal, with delicate beading along the bodice. I stayed up late perfecting every stitch. Lena had wanted a lacy dress that made her feel like a princess.
“I know it’s foolish, darling,” she said. “When I married Adam’s father all those years ago, I wore a shapeless white dress that did absolutely nothing for my figure. I want to live my dream wedding dress now.”
Lena had given me her measurements, and oddly enough, they matched mine.
A woman sewing | Source: Midjourney
I tried not to think about it. But it wasn’t a surprise. The entire time I had been dating Adam, Lena was always at Pilates or yoga or swimming with her friends.
The morning of the wedding arrived. I packed the dress into a garment bag, loaded it carefully into my car, and drove to the venue. It was a gorgeous country estate tucked away like something out of a fairy tale.
If I ever got married, I could see myself using this as a venue contender.
A wedding venue | Source: Midjourney
The moment I pulled up, unease curled in my stomach.
Something’s wrong, I thought. But I shook it off.
Clutching the garment bag, I walked inside. Soft music drifted through the air, and guests milled about in suits and gowns, their laughter a low hum. But then I saw it.
A massive banner near the altar, shimmering under the soft light.
A smiling woman | Source: Midjourney
It displayed the names of the couple getting married.
I froze right there.
It wasn’t Lena’s name.
It was Adam’s name. And mine.
Welcome to the nuptials of Adam & Hayley
A shocked woman | Source: Midjourney
I blinked, my mind short-circuiting. My heart was racing so fast it felt like it might explode.
“What… what is this?” I whispered aloud.
“Hayley,” a voice said from behind me.
His voice, Adam’s voice, made me jump. I turned around, and there he was.
Adam.
A man in a suit | Source: Midjourney
He looked older, his jaw sharper, his eyes softer. He wasn’t smiling, though. He just stood there, hands at his sides, looking at me like I was the only person in the room.
“What is this?” I demanded, my voice shaking. “Why is my name on that banner? What’s happening?”
He took a slow step toward me, regret written all over his face.
“Please, just let me explain.”
A close up of a man | Source: Midjourney
I wanted to scream. I wanted to run. But I just couldn’t move.
“You’ve got two minutes,” I said, folding my arms tightly across my chest.
He took a deep breath.
“Three years ago, I made the biggest mistake of my life.”
Yeah, no kidding, I thought bitterly, but I stayed quiet.
A woman with folded arms | Source: Midjourney
“I was going to propose to you, Hayley,” he said. “I had the ring. I had everything planned. And then… she showed me something.”
“She?” I whispered, already knowing who.
“Your… my ex. Miranda,” he looked away, his voice thick with regret. “She showed me a video of you all on holiday. Thailand, I think it was. And you were drinking and shouting that you didn’t want kids. She told me that it was recent, that you’d been lying to me about wanting a family. Especially with me. It crushed me, Hayley. I thought I didn’t know you at all.”
An angry woman | Source: Midjourney
The air whooshed out of my lungs. I remembered the video. It was years ago, we had been on a girls’ trip, and I was venting after a drunken spat with someone who assumed all women had to want kids. The same man who made his wife take care of their kids while he enjoyed his beer on the beach.
It had nothing to do with Adam and everything to do with wanting to be heard.
“You didn’t think to ask me?” I choked out. “You didn’t think that you could have taken five minutes to ask me about that video?”
A surprised woman | Source: Midjourney
“I know, Hayley,” he said, shaking his head. “I was stupid. I was already vulnerable, and she got into my head. I believed Miranda. I believed everything she said. And I let you go. Then she admitted the truth.”
“What?” I gasped.
“Months ago. She slipped up during an argument. She told me the video was old, and she knew I’d overreact. She said that she wanted me for myself and couldn’t stand that you had me.”
A woman holding her head | Source: Midjourney
Tears stung my eyes. I couldn’t believe what I was hearing. She’d destroyed everything we had, and he let her.
“I ended things with her that night,” he continued. “And I’ve spent every day since trying to figure out how to fix this. How to win you back.”
I shook my head, still completely overwhelmed.
“And this?” I gestured around. “What the heck is this?”
His lips curved into a small, nervous smile.
A wedding setting | Source: Midjourney
“This is me not waiting any longer…”
Adam reached into his pocket and pulled out a small, black velvet box. Then he dropped to one knee.
“Hayley, I love you. I never stopped. I know I don’t deserve your forgiveness, but I’m asking for it anyway. Will you marry me? Right here, right now?”
I stared at him, my world spinning. Then, out of nowhere, it hit me.
A ruby engagement ring | Source: Midjourney
Lena.
She’d planned this. She’d asked me to make the dress because she knew.
And the truth? I still loved him.
So, I whispered my answer.
“Yes, Adam.”
Lena appeared almost instantly, carrying flowers and beaming like a woman who’d just pulled off the heist of the century.
A smiling older woman | Source: Midjourney
“You said yes!” she cried, hugging me tightly. “I’m so sorry for how I treated you before, Hayley. I didn’t see how much you meant to Adam until it was too late. Thank you for giving him another chance.”
Stylists and makeup artists seemed to appear out of nowhere. My parents showed up, looking both stunned and delighted. No one knew if I’d say yes, but they’d all been ready.
I changed into the dress I’d made with my own hands, realizing it had been meant for me all along.
Hair and makeup artists | Source: Midjourney
When Adam and I stood together at the altar, his hand in mine, I felt something I hadn’t felt in years.
Peace.
After the ceremony, the crowd had thinned, and the music played softly in the background. I stood on the balcony of the venue, the crisp evening air cooling my flushed cheeks.
My hands rested on the railing as I stared at the horizon, trying to process everything that had happened.
A smiling woman | Source: Midjourney
“Hey.”
Adam’s voice came from behind me. I turned to see him standing there, tie loosened, the soft glow of string lights making his eyes look even warmer.
“Hey,” I said quietly, my lips curving into a small smile.
He stepped beside me, his arm brushing against mine as we both looked out into the night.
“Are you okay?” he asked.
A smiling groom | Source: Midjourney
I let out a soft laugh, shaking my head.
“I don’t even know what I am right now. Happy? Overwhelmed? Still waiting for someone to yell ‘April Fools’?”
He chuckled, his gaze softening.
“It’s real, Hayley. I promise.”
We fell silent for a moment before he spoke again, his voice more serious.
A laughing bride | Source: Midjourney
“I don’t deserve this. You. I know I messed up. I let someone else’s lies break something beautiful, and I’ve hated myself for it every day since.”
I turned to face him, my heart tightening.
“You should’ve talked to me, Adam. I would have told you the truth. You hurt me so much when you left.”
His face crumbled just a little, his jaw flexing.
A woman looking pensive | Source: Midjourney
“I know. And I’ll spend the rest of my life making it up to you, if you’ll let me.”
I stared at him for a long moment, searching his face for any doubt, any hesitation.
But there was none.
“I’m here, aren’t I?” I whispered.
His lips curved into a smile, a mixture of relief and love.
A smiling man | Source: Midjourney
“Yeah, you are,” he said.
He took my hand and kissed my knuckles, lingering for just a moment.
“This time, I’ll get it right.”
I smiled back, the truth settling deep in my chest.
“This time, we will.”
“Come, love. Let’s go get some cake and champagne.”
But before we left the balcony, he pulled me into his arms, and for the first time in years, I felt like I was exactly where I was meant to be.
A wedding cake | Source: Midjourney
On the day of Mabel and Adam’s wedding, they’re stuck in a limousine as they crawl along the freeway, thanks to traffic. Instead of keeping her mother’s guests entertained, Mabel’s daughter, Amanda, takes over the wedding, stealing the limelight. Will Mabel retaliate at the wedding or just let Amanda learn her lesson another way?
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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