The fact that the legendary Robin Williams died ten years ago is astounding. The late actor was a titan of the film business, a hilarious actor with almost no competition, whose death left a lasting impact on society. His death was undoubtedly the result of unfortunate circumstances, and his legacy continues to be profound.
That people are still talking about his life and legacy and that many of them conjecture about what may have occurred if his fortune and destiny had turned out differently should not come as a surprise.
The last words William ever said to him were relayed by Billy Connolly, a comedian and close friend of the actor, over ten years after the untimely death of the Good Will Hunting star. and they’re exactly as heartwarming as you might anticipate… It’s true that humor and Robin Williams go hand in hand.
Throughout his colorful career, Williams became one of the funniest men to have ever graced our screens. Ten years after his death, people are still laughing at the comedy he created, which combines gut-busting hilarity with strange, wonderful, flawed, and fabulous characters.
However, tragedy also plagued Williams’ life in this instance, to the extent that the actor believed life was not worth living at all. On August 11, 2014, Williams, 63, was found dead at home; it appeared that he had committed suicide.
Williams had issues like alcoholism despite enjoying great success in his acting career. In 2014, Williams spent three weeks at the Hazelden facility in Minnesota in an effort to deepen his commitment to recovery.
According to reports, the Jumanji actor battled alcoholism and cocaine abuse in the early 1980s until giving up when his pal John Belushi passed away from an overdose in 1982. Following his passing in 2014, the late Hollywood icon’s representative stated that he had been “battling severe depression.” His wife Susan Schneider subsequently revealed further information on his demise, including the fact that he had only been diagnosed with Parkinson’s disease a few months before he passed away.
Williams had Lewy body dementia (LBD), which resulted in significant alterations to his personality, mobility, temperament, memory, reasoning, sleep patterns, and mood, according to the results of an autopsy.
Needless to say, Williams’ passing had a terrible effect on a lot of people, including his closest friends and family.
One figure who definitely belonged in the first category was Sir Billy Connolly, who has been diagnosed with Parkinson’s disease. When asked what he would have done differently if he had known Williams intended to commit suicide, the comedian and actor said, “You have to give a guy the position that he’s wise enough to make up his own mind.” Connolly stated, “I don’t think so,” in response to the topic of whether or not he would have tried to save his own life.
The 81-year-old Connolly also revealed that he and Williams had talked on the phone a lot about their experiences with Parkinson’s disease and would often express how much they loved and cared for each other. When Connolly appeared on the BBC program In My Own Words, he discussed his relationship with Williams.
The week before Williams passed suddenly, he said, the actor had called to ask him to dinner. “I love you,” he remarked to me over dinner when he called and said, “Let’s have dinner.” Connolly thought back to their last dinner together. I conveyed my appreciation. He said, “Do you believe me?” “Obviously, I do,” I remarked. “You have my undying love,” he declared. That was great, in my opinion.
My initial thought was, “How strange, how strange for him to say that, it’s not like him normally.” Connolly said, “He died during the weekend. I hope you find peace, Robin Williams.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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