The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Fans Say Marlo Thomas ‘Destroyed’ Her Beauty with Surgery: How She Would Look Today Naturally
Marlo Thomas, who is 86 years old, has had a successful acting career spanning many years. Her performances in shows like “Ocean 8,” “The Real Blonde,” and “A Magical Christmas Village” have made her well-known. Even though she produced a large body of work, her natural beauty from her “That Girl” days is what many admirers remember her for. But over time, Thomas’s appearance has changed dramatically, leading many to surmise that plastic surgery was a major factor.
Conjectures and AI-Created Pictures
Artificial intelligence-generated images indicate that, had Thomas not undergone plastic surgery, she may have aged normally with little wrinkles, a well-defined nose, and a charming grin on her elevated cheeks. The discussion on how plastic surgery has changed her appearance and whether these modifications are good or bad is fueled by these photos.
Public Responses to Her Changes
Fans weren’t slow to react when photos of Marlo Thomas’s altered face from 1968 to 2024 appeared online. “She was much prettier when she was on ‘That Girl’ before all the surgeries,” a user said. Her nose is awful right now. “She was so pretty, too bad she destroyed it with surgery,” said a dejected person. Others who believe she has overindulged in cosmetic surgeries echo these complaints.
Fans’ worries and complaints
A lot of admirers think Thomas was more attractive before having plastic surgery. There’s way too much work done, a user said. Before she struck the knife, she was stunning. Oh no. Commenters who expressed agreement included “I agree” and “So true.”A few admirers wished she had approached cosmetic treatments with more caution. Some nevertheless acknowledge her efforts in spite of these criticisms; one individual said, “Too many surgeries.” She is a remarkable woman, though.
Thomas’s Reaction to What People Think
Even with the criticism, Marlo Thomas is unmoved. She related a story about how she uploaded a photo of her husband Phil Donahue with their granddaughter and got comments implying that he had plastic surgery, even though he hasn’t. Thomas brushed these remarks aside, claiming that being well-groomed does not always imply having had surgery. She says, “But even if you did want to—go ahead!” in support of the notion that people should feel free to undergo plastic surgery if they so want.
Cher’s Impact and Personal Independence
Marlo Thomas like the way singer Cher responds to criticism over her own cosmetic procedures. Cher reportedly asserted that she could place her nose on her butt if she so desired, emphasizing the value of having personal control over one’s physical appearance. Thomas agrees, stating that she is unconcerned with the decisions that other people make about their bodies.
Individual Choices and Family Impact
It has been stated that Thomas, who has been outspoken about her body image, had plastic surgery to alter the curve of her nose. Her father Danny Thomas, who also underwent nose surgery, reportedly told her that if she inherited his nose, she should get into comedy. Though he encouraged her to accept her natural look, Thomas decided to have cosmetic surgery.
Influence on Popular Culture
Marlo Thomas’s plastic surgery has had an impact that goes beyond her individual encounters. The television writer Mindy Schneider disclosed in her autobiography, “Not a Happy Camper,” that her mother desired for her to undergo a nose job performed by the same physician who treated Thomas. This illustrates the demands of cosmetic surgery in the entertainment business as well as its wider cultural impact.
Accepting Personal Decisions
Marlo Thomas ultimately argues that individuals need to be free to make decisions regarding their bodies without fear of condemnation or censure. Her position emphasizes how important it is to accept people’s choices, regardless of whether they include cosmetic surgery or other personal choices.
In conclusion, Marlo Thomas’s change through plastic surgery has generated a great deal of public discussion, yet her dedication to individual freedom and body positivity is still evident. Her path, whether praised or criticized, sheds insight on the nuanced relationship between individual choice, beauty standards, and notoriety.
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